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2 edition of Placental alkaline phosphatase as a tumour marker for ovarian cancer. found in the catalog.

Placental alkaline phosphatase as a tumour marker for ovarian cancer.

Patricia McNulty

Placental alkaline phosphatase as a tumour marker for ovarian cancer.

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Published by The Author] in [S.l .
Written in English


Edition Notes

Thesis (M. Sc. (Biomedical Sciences)) - University of Ulster, 1995.

The Physical Object
Pagination52p.,tables :
Number of Pages52
ID Numbers
Open LibraryOL20998181M

phosphatase (ALP). Placental alkaline phosphatase (PLAP) has been shown to be a oncodevelopmental gene product, which is most frequently produced by some human malignant tumors and tumor-derived cell lines, such as ovarian cancer, cervical cancer and testicular cancer. 1~ It has.


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Placental alkaline phosphatase as a tumour marker for ovarian cancer. by Patricia McNulty Download PDF EPUB FB2

Cruickshank DJ, Fullerton WT, Klopper A. The clinical significance of pre-operative serum CA in ovarian cancer. Br J Obstet Gynaecol. Jul; 94 (7)– Vergote I, Onsrud M, Nustad K. Placental alkaline phosphatase as a tumor marker in ovarian cancer. Obstet Gynecol. Feb; 69 Cited by: Alkaline phosphatase, placental type is a membrane-bound glycosylated dimeric enzyme, also referred to as the heat-stable form, that is expressed primarily in the placenta, although it is closely related to the intestinal form of the enzyme as well as to the placental-like form.

Clinical significance. PLAP is a tumor marker, and ovarian Aliases: ALPP, ALP, PALP, PLAP, PLAP-1. Stigbrand T, Riklund K, Tholander B, et al. Placental alkaline phosphatase (PLAP)/PLAP-like alkaline phosphatase as tumour marker in relation to CA and TPA for ovarian epithelial tumours.

Eur J Gynaecol Oncol ; Cited by: 6. Placental alkaline phosphatase (PLAP) is a promising ovarian cancer biomarker. Here, we describe the isolation, affinity-maturation and characterization of two fully human monoclonal antibodies (termed B10 and D9) able to bind to human PLAP with a dissociation constant (K d) of 10 and 30 nM, ability of B10 and D9 antibodies to recognize the native antigen was confirmed by Cited by: 9.

Serum marker potential of placental alkaline phosphatase-like activity in testicular germ cell tumours evaluated by H 17E2 monoclonal antibody assay.

Brl Cancer51, 8. Horwich A, Tucker DF, Peckham MJ. Placental alkaline phosphatase as a tumour marker in seminoma using the H17E2 monoclonal antibody assay.

Brl Cancer51, Cited by: A nonspecific marker for pancreatic, pituitary, and placental tumors; elevated levels may be present in pancreatic cancer. Beta Subunit HCG. A serum test used as a tumor marker for choriocarcinoma and for testicular carcinoma.

Beta-HCG levels are never found in normal men. When the presence of B-HCG is detected in serum it always indicates a.

A tumor marker is a biomarker found in blood, urine, or body tissues that can be elevated by the presence of one or more types of are many different tumor markers, each indicative of a particular disease process, and they are used in oncology to help detect the presence of cancer.

An elevated level of a tumor marker can indicate cancer; however, there can also be other causes of. Tumor markers are biological substances that can be detected in the blood, urine, or body tissue of some tumor patients.

Although some tumor markers may aid in the diagnosis of cancer, they are primarily used for monitoring treatment response and detecting cancer recurrence. Tumor markers are not reliable screening or diagnostic markers due to their low sensitivity (i.e., not elevated in all.

T Ind, R Iles, J Shepherd, and T Chard, “Serum concentrations of cancer antigenplacental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer,” British Journal of Obstetrics and Gynaecology, vol.no.

9, pp. –, Cited by: 5. Clinica Chimica Acta, () Eisevier CCA Short Communication Placental-like alkaline phosphatase from ovary and ascites of a patient with a malignant ovarian tumour Iwao Koyama1, Ulf Stendahl 2 and Torgny Stigbrand1 Departments of l Physiological Chemistry and 2 Oncological Gynaecology, University of Umea, Umea (Sweden) (Received 14 June ; revision received and Cited by: 6.

Placental-like alkaline phosphatase, part of a family of alkaline phosphatases with 4 members germ cell neoplasms, including the precursor lesion germ cell neoplasia in situ and overt germ cell tumors (testicular, ovarian and extra gonadal) Mainly a marker of seminoma (also dysgerminoma and germinoma of the brain) - positive in up to %.

Lange PH, Millan JL, Stigbrand T, Vessella RL, Ruoslahti E, Fishman WH () Placental alkaline phosphatase as a tumour marker for seminoma. Cancer Res – Google Scholar McDicken IW, McLaughlin PJ, Tromans PM, Luesley DM, Johnson PM () Detection of placental-type alkaline phosphatase in ovarian by: Placental-type alkaline phosphatase in cervical neoplasia Article (PDF Available) in British Journal of Cancer 55(2) March with 13 Reads How we measure 'reads'.

Placental alkaline phosphatase (PLAP) was measured by an immunoradiometric assay using the monoclonal antibody C2 (PLAP-C2). Serum samples of patients with epithelial ovarian cancer were analyzed, and the results were compared with CA by: Summary.

Tumor marker identification in testicular cancer has contributed to early detection and monitoring of non-seminomatous disease. A placental alkaline phosphatase-like (PLAP-like) enzyme derived from seminomas has recently been focused upon as a possible marker for this by:   Placental alkaline phosphatase (PLAP) exists in trophoblast cells of normal human mature placenta, seminomas of testis, and ovarian carcinomas.

3 It is well known that PLAP immunohistochemical identification is useful in testicular GCT diagnosis. 5,19,24 Pathologically, intracranial GCTs are similar to testicular and other extragonadal GCTs.

20 Cited by: 1. Serum placental-like alkaline phosphatase (PLAP): A novel combined enzyme linked immunoassay for monitoring ovarian cancer Article (PDF Available) in Journal of Clinical Pathology 42(1) Developmental phase-specific alkaline phosphatase isoenzymes of human placenta and their occurrence in human cancer.

Cancer Res. ;36(7 PT 1) Okensina AB, Donaldson D, Lascelles PT, Morris P. Effect of gestational age on levels of serum alkaline phosphatase isoenzymes in healthy pregnant women. For patients with ovarian cancer and carcinoma of the breast the On the value of placental alkaline phosphatase as a marker for gynaecological malignancy.

Acta Obst. Gyn. (in press) III J.L. Millan, G. Beckman, A. Jeppsson and T. Stigbrand: Genetic variants of placental alkaline phosphatase as detected by a monoclonal antibody. Hum. Genet Cited by: 1. Placental alkaline phosphatase, PLAP Placental alkaline phosphatase is a 70 kD membrane-bound alkaline phosphatase metal loenzyme, encoded by a gene on chromosome 2q.

Its function is uncertain. Immunohistochemical expression. Background staining may make interpretation difficult 2.

Various types of ovarian, testicular and extragonadal germ cell. I. Enzymes as tumour markers A. Alkaline phosphatase [ALP] • ALP is mainly present in liver, biliary tract, bone and placenta • Increased ALP can be seen in – liver cancer – Cancer of biliary tract – Metastatic cancer with bone or liver involvement – testicular seminomas B.

Western blot was performed using Anti-Placental Alkaline Phosphatase Monoclonal Antibody (3E5), (Product # MA) and a 60 kDa band corresponding to Placental Alkaline Phosphatase was observed in PANC-1 and SK-BR-3 with a faint uncharacterized bands (*) at ~36 kDa when compared to low expressing cell lines such as HeLa and PC Pretreatment serum levels of the antigens CA, tissue polypeptide Antigen (TPA), Carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) were determined in samples from women with adnexal masses.

At laparotomy 48% of patients had epithelial ovarian carcinoma, 9% had tumors of low malignant potential, and 8% suffered from malignancies of other by:   THE activity of serum alkaline phosphatase increases during the last trimester of pregnancy.

Results of studies employing heat stability1, differential inhibition2 and starch gel electrophoresis3. Human placental (hPLAP) and germ cell (PLAP-like) alkaline phosphatases are polymorphic and heat-stable enzymes. This study was designed to develop specific immunoassays for quantifying hPLAP and PLAP-like enzyme activity (EA) in sera of cancer patients, pregnant women, or smokers.

A new combined enzyme linked immunoassay (ELISA) was developed to measure both serum placental-like alkaline phosphatase (PLAP) activity (PLAPA) and concentration (PLAPC) in the same microtitre plate using an Imperial Cancer Research Fund monoclonal antibody, designated H17E2. PLAP A and PLAP C were determined together with an existing marker, CA in serial samples Cited by:   Applications in ovarian cancer detection Early detection of ovarian cancer through the measurement of CA, usually in combination with other modalities (eg, bimanual pelvic examination, transvaginal ultrasonography), is the most promising application of this tumor marker, permitting effective triage of patients for primary surgery.

Tumour secreting placental alkaline phosphatase is. Carcinoid tumour B. Arrhenoblastoma C. Granulosa cell tumour D. Dysgerminoma.

Correct answer: D. Dysgerminoma. Seminoma of testis: Histologically indistinguishable from dysgerminoma of ovary. Dysgerminoma corresponds to seminoma of the testis. It is usually seen in young women or children. Placental alkaline phosphatase is a 70 kD membrane-bound alkaline phosphatase metal loenzyme, encoded by a gene on chromosome 2q.

Its function is uncertain. Immunohistochemical expression. Various types of ovarian, testicular and extragonadal germ cell tumours: seminoma.

embryonal carcinoma. gonadoblastoma. yolk sac tumour. choriocarcinoma. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation.

Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. It is part of the phosphatase enzyme found in the prostate gland, and is used to monitor prostate cancer.

How is the PAP tumor marker unreliable. It can be found in patients with benign prostatic hyperplasia. This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of childhood central nervous system germ cell tumors.

It is intended as a resource to inform and assist clinicians who care for cancer patients. Ovarian germ cell tumors (OGCTs) comprise 20–25% of all ovarian cancers arising from germ cells of ovary. Mature teratoma (dermoid) is the only benign and commonest germ cell tumor.

Only 3–5% germ cell tumors are malignant, dysgerminomas being the most common. These tumors occur in adolescents and reproductive age group. Hence, its association with pregnancy is not : Mamta Gupta, Vandana Saini. Placental Isoenzymes: Placental isoenzymes are found in pregnancy and begin rising late in first trimester.

They continue to rise up to one month after the termination of pregnancy. These enzymes are also associated with some malignant diseases such as ovarian cancer, sarcomas, pancreatic, and stomach cancers.

Serum tumor markers are useful to evaluate a cancer's response to treatment, for early detection of cancer relapse, and, in some cases, to diagnose malignancy. In this paper, we present two patients with significantly elevated serum tumor markers without evidence of malignant disease.

An year-old patient suffering from autoimmune hepatitis had markedly increased alpha-fetoprotein (aFP Cited by: Outpatient appointments.

We know that NHS services will come under intense pressure as the coronavirus spreads, and as a Trust we need to redirect staff, free up staff for refresher training and carry out any works as necessary, so we are able to maximise capacity.

ALPP - Alkaline Phosphatase, Placental. Looking for abbreviations of ALPP. It is Alkaline Phosphatase, Placental. Alkaline Phosphatase, Placental listed as ALPP Alkaline Phosphatase, Placental; Alkaline Phosphatase-Anti Alkaline Phosphatase; Alkaline Phosphatase-Labeled Anti-Salmonella; alkaline phosphatase-positive.

Placental alkaline phosphatase, abbreviated PLAP, is a common immunostain used for assessing suspected germ cell tumours. It has largely been replaced by OCT4. placental alkaline phosphatase: Abbreviation: PLAP A form of heat-stable alkaline phosphatase released by trophoblast cells in the human placenta, i.e.

during pregnancy. Cancers of colon, lung, ovary, and testes, esp. seminoma, produce the enzyme ectopically. See also: phosphatase. Placental Alkaline Phosphatase (PLAP) reacts with a membrane-bound isozyme (Regan and Nagao type) of PLAP occurring in the placenta during the 3rd trimester of gestation.

This antibody is highly specific to PLAP and shows no cross-reaction with other isozymes of alkaline phosphatases. It is useful in the identification of testicular germ cell tumors and in separating thymic neoplasms from germ. TY - JOUR. T1 - Placental alkaline phosphatase positivity in metastatic melanoma.

AU - Frieling, Gretchen W. AU - Al-Zaid, Tariq. AU - Prieto, VictorCited by: 2.Ovarian Cancer Community k Members abnormal alkaline phosphatase rosie Went to the dr.

and my alkaline phosphatase was low at 19 ( norms) what does this mean? Read 2 Responses. Follow - 1. 2 Responses nyc lady. Rosie - not really certain if you are in the right place.Mr Ind started his specialist training at St Bartholomew's Hospital.

After two years he took a short break in clinical practice to study for a doctoral thesis in which he developed an assay for placental alkaline phosphatase and assessed its use as a tumour marker.

The .